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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
12.42
Human Site:
S312
Identified Species:
27.33
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
S312
I
D
S
N
I
A
F
S
V
N
A
S
D
K
G
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
S312
I
D
S
N
I
A
F
S
V
N
A
S
D
K
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
S313
I
D
S
N
I
A
F
S
V
N
S
S
D
K
G
Rat
Rattus norvegicus
Q6T3U3
1331
146397
N314
V
V
S
N
R
N
K
N
K
A
E
G
P
Q
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
T306
H
R
D
N
G
K
I
T
C
G
E
R
L
G
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
A257
V
L
I
C
I
C
S
A
G
L
S
Y
M
R
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
S315
Q
V
D
G
N
D
V
S
D
E
M
P
Y
S
E
Honey Bee
Apis mellifera
XP_624752
1358
152373
T313
F
D
D
E
E
Q
S
T
F
I
E
R
L
G
A
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
T315
D
Y
T
N
L
R
Q
T
Q
S
G
E
E
S
P
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
N348
V
N
S
V
N
G
A
N
R
K
E
I
S
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
L263
P
C
F
S
L
S
V
L
I
F
Y
T
I
C
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
100
N.A.
N.A.
N.A.
93.3
13.3
N.A.
N.A.
6.6
N.A.
6.6
N.A.
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
100
33.3
N.A.
N.A.
13.3
N.A.
33.3
N.A.
6.6
13.3
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
28
10
10
0
10
19
0
0
0
19
% A
% Cys:
0
10
0
10
0
10
0
0
10
0
0
0
0
10
0
% C
% Asp:
10
37
28
0
0
10
0
0
10
0
0
0
28
0
10
% D
% Glu:
0
0
0
10
10
0
0
0
0
10
37
10
10
10
28
% E
% Phe:
10
0
10
0
0
0
28
0
10
10
0
0
0
0
0
% F
% Gly:
0
0
0
10
10
10
0
0
10
10
10
10
0
19
28
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
28
0
10
0
37
0
10
0
10
10
0
10
10
0
10
% I
% Lys:
0
0
0
0
0
10
10
0
10
10
0
0
0
28
0
% K
% Leu:
0
10
0
0
19
0
0
10
0
10
0
0
19
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% M
% Asn:
0
10
0
55
19
10
0
19
0
28
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
0
10
10
0
10
% P
% Gln:
10
0
0
0
0
10
10
0
10
0
0
0
0
10
0
% Q
% Arg:
0
10
0
0
10
10
0
0
10
0
0
19
0
10
0
% R
% Ser:
0
0
46
10
0
10
19
37
0
10
19
28
10
19
0
% S
% Thr:
0
0
10
0
0
0
0
28
0
0
0
10
0
0
0
% T
% Val:
28
19
0
10
0
0
19
0
28
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
10
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _